|(G;G)||2.5||6x higher risk of rheumatoid arthritis|
The HLA-DRB1*0401 allele has been associated with higher risk for rheumatoid arthritis, and in particular, rheumatoid vasculitis. The association is seen particularly for individuals carrying two copies of, i.e. homozygous for, the allele. The reported odds ratio for rs660895(G;G) homozygotes is 6.2 (CI: 1.01 - 37.9). [PMID 15529352]
The risk for rheumatoid arthritis may be higher for individuals carrying one copy (one "dose") of the HLA-DRB1*0401 allele, if they also carry a different HLA-DRB1 risk allele. In particular, *0401/*0404 individuals are reported to have an odds ratio for rheumatoid vasculitis of 4.1 (CI: 1.1 - 16.2), and *0401/*0101 individuals have an odds ratio of 4.0 (CI: 1.4 - 11.6). [PMID 15529352]
- (A;A) is 0 dose of HLA-DRB1*0401
- (A;G) is 1 dose of HLA-DRB1*0401
|Title||TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study|
|Odds Ratio||3.62 [NR]|
[PMID 24270849] rs660895 was found to be associated with rheumatoid arthritis based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.
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|Odds Ratio||1.3400 None|
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|qualified_impact||Insufficiently evaluated pathogenic|
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