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rs686

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(G;G) 0
Make rs686(A;A)
Make rs686(A;G)
ReferenceGRCh38 38.1/141
Chromosome5
Position175441697
GeneDRD1
is asnp
is mentioned by
dbSNPrs686
ebirs686
HLIrs686
Exacrs686
Varsomers686
Maprs686
PheGenIrs686
hapmaprs686
1000 genomesrs686
hgdprs686
ensemblrs686
gopubmedrs686
geneviewrs686
scholarrs686
googlers686
pharmgkbrs686
gwascentralrs686
openSNPrs686
23andMers686
23andMe allrs686
SNP Nexus

SNPshotrs686
SNPdbers686
MSV3drs686
GWAS Ctlgrs686
GMAF0.382
Max Magnitude0
? (A;A) (A;G) (G;G) 28

Implicated as part of a haplotype of the dopamine D1 receptor DRD1 gene associated with autism spectrum disorders in families having only affected males. The haplotype is rs265981(C)-rs4532(A)-rs686(T) as published, though not necessarily as oriented in dbSNP.[PMID 18205172]

OMIM188890
DescTOBACCO ADDICTION, SUSCEPTIBILITY TO
Variant
Relatedalso
OMIM126449
DescDOPAMINE RECEPTOR D1; DRD1
Variant
Relatedalso


[PMID 20456319] Association of polymorphisms in the BDNF, DRD1 and DRD3 genes with tobacco smoking in schizophrenia

[PMID 18092181] Significant association of DRD1 with nicotine dependence.

[PMID 18341651] A haplotype of the DRD1 gene is associated with alcohol dependence.

[PMID 18937842OA-icon.png] The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis.

[PMID 19135651OA-icon.png] Differential allelic expression of dopamine D1 receptor gene (DRD1) is modulated by microRNA miR-504.

[PMID 19500151OA-icon.png] Heroin addiction in African Americans: a hypothesis-driven association study.

[PMID 21332319] Gene-gene interaction analyses between NMDA receptor subunit and dopamine receptor gene variants and clozapine response.

[PMID 21955727] An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia.

[PMID 22574669] Dopamine receptors D1 and D2 are related to observed maternal behavior.