The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23). [PMID 17179172]
In a study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).[PMID 18313765]
In another report [PMID 15838509], a summary indicates the following regarding disease and odds ratio (OR)for rs7528684:
- for rheumatoid arthritis: OR = 2.15 (CI = 1.58â€“2.93), from 830 cases and 658 controls;
- for SLE: OR = 1.49 (CI = 1.16â€“1.92), from 564 cases;
- for Graves' disease : OR = 1.79 (CI = 1.34â€“2.39), from 351 cases;
- for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07â€“2.47), from 158 cases.
[PMID 19438904] Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease
[PMID 21885492] FCRL3 -169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression
|Title||Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.|
|Odds Ratio||1.5200 [NR]|
[PMID 16519819] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.
[PMID 16859508] Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?
[PMID 17389014] Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.
[PMID 18556337] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
[PMID 18759263] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.
[PMID 19050767] Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations.
[PMID 19180233] Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.
[PMID 19452015] Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.
[PMID 19877046] The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.
[PMID 22341374] Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.
[PMID 23505439] A Refined Study of FCRL Genes from a Genome-Wide Association Study for Graves' Disease
[PMID 23512175] Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis
[PMID 24117236] The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: An updated meta-analysis
[PMID 23564408] The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population.
[PMID 26051414] FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population
[PMID 25566937] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis