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rs7528684

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 0 normal
(G;G) 1.2x risk
ReferenceGRCh38 38.1/141
Chromosome1
Position157701026
GeneFCRL3
is asnp
is mentioned by
dbSNPrs7528684
ebirs7528684
HLIrs7528684
Exacrs7528684
Varsomers7528684
Maprs7528684
PheGenIrs7528684
hapmaprs7528684
1000 genomesrs7528684
hgdprs7528684
ensemblrs7528684
gopubmedrs7528684
geneviewrs7528684
scholarrs7528684
googlers7528684
pharmgkbrs7528684
gwascentralrs7528684
openSNPrs7528684
23andMers7528684
23andMe allrs7528684
SNP Nexus

SNPshotrs7528684
SNPdbers7528684
MSV3drs7528684
GWAS Ctlgrs7528684
GMAF0.4357
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population. [PMID 16176992OA-icon.png]

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23). [PMID 17179172OA-icon.png]

In a study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).[PMID 18313765]

In another report [PMID 15838509OA-icon.png], a summary indicates the following regarding disease and odds ratio (OR)for rs7528684:

  • for rheumatoid arthritis: OR = 2.15 (CI = 1.58–2.93), from 830 cases and 658 controls;
  • for SLE: OR = 1.49 (CI = 1.16–1.92), from 564 cases;
  • for Graves' disease : OR = 1.79 (CI = 1.34–2.39), from 351 cases;
  • for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07–2.47), from 158 cases.

[PMID 18087673] rs7528684 rs3792876 and rs2268277 failed to showed a statistically significant association with rheumatoid arthritis

[PMID 18556175] rs7528684, rs11264799, rs945635 and rs3761959 were not associated with systemic lupus erythematosus (SLE) in a study of 248 Chinese Han patients.


[PMID 19438904] Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease


[PMID 21885492] FCRL3 -169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression

GWAS snp
PMID [PMID 21829393OA-icon.png]
Trait
Title Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Risk Allele T
P-val 1E-11
Odds Ratio 1.5200 [NR]


[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.


[PMID 16859508OA-icon.png] Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?


[PMID 17389014] Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.


[PMID 18556337OA-icon.png] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).


[PMID 18759263OA-icon.png] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.


[PMID 19050767OA-icon.png] Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations.


[PMID 19180233OA-icon.png] Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.


[PMID 19452015OA-icon.png] Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.


[PMID 19877046OA-icon.png] The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.


[PMID 22341374] Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.


[PMID 23505439OA-icon.png] A Refined Study of FCRL Genes from a Genome-Wide Association Study for Graves' Disease


[PMID 23512175] Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis


[PMID 24117236] The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: An updated meta-analysis


[PMID 23564408] The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population.


[PMID 26051414] FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population


[PMID 25566937OA-icon.png] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis