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From SNPedia

Geno Mag Summary
(A;A) 0 normal
(A;G) 0 normal
(G;G) 1.2x risk
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
1000 genomesrs7528684
23andMe allrs7528684
SNP Nexus

GWAS Ctlgrs7528684
Max Magnitude0
? (A;A) (A;G) (G;G) 28
rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population. [PMID 16176992OA-icon.png]

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23). [PMID 17179172OA-icon.png]

In a study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).[PMID 18313765]

In another report [PMID 15838509OA-icon.png], a summary indicates the following regarding disease and odds ratio (OR)for rs7528684:

  • for rheumatoid arthritis: OR = 2.15 (CI = 1.58–2.93), from 830 cases and 658 controls;
  • for SLE: OR = 1.49 (CI = 1.16–1.92), from 564 cases;
  • for Graves' disease : OR = 1.79 (CI = 1.34–2.39), from 351 cases;
  • for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07–2.47), from 158 cases.

[PMID 18087673] rs7528684 rs3792876 and rs2268277 failed to showed a statistically significant association with rheumatoid arthritis

[PMID 18556175] rs7528684, rs11264799, rs945635 and rs3761959 were not associated with systemic lupus erythematosus (SLE) in a study of 248 Chinese Han patients.

[PMID 19438904] Clinical associations of the genetic variants of CTLA-4, Tg, TSHR, PTPN22, PTPN12 and FCRL3 in patients with Graves' disease

[PMID 21885492] FCRL3 -169C/C Genotype Is Associated with Anti-citrullinated Protein Antibody-positive Rheumatoid Arthritis and with Radiographic Progression

GWAS snp
PMID [PMID 21829393OA-icon.png]
Title Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
Risk Allele T
P-val 1E-11
Odds Ratio 1.5200 [NR]

[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16859508OA-icon.png] Association of the FCRL3 gene with rheumatoid arthritis: a further example of population specificity?

[PMID 17389014] Epistatic interaction between FCRL3 and MHC in Spanish patients with IBD.

[PMID 18556337OA-icon.png] Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

[PMID 18759263OA-icon.png] Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort.

[PMID 19050767OA-icon.png] Association between polymorphisms of FCRL3, a non-HLA gene, and Behcet's disease in a Chinese population with ophthalmic manifestations.

[PMID 19180233OA-icon.png] Reduced neutrophil count in people of African descent is due to a regulatory variant in the Duffy antigen receptor for chemokines gene.

[PMID 19452015OA-icon.png] Polymorphisms of FCRL3 in a Chinese population with Vogt-Koyanagi-Harada (VKH) syndrome.

[PMID 19877046OA-icon.png] The FCRL3-169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells.

[PMID 22341374] Genetic association study of polymorphisms FOXP3 and FCRL3 in women with endometriosis.

[PMID 23505439OA-icon.png] A Refined Study of FCRL Genes from a Genome-Wide Association Study for Graves' Disease

[PMID 23512175] Fc receptor-like 3 (FCRL3) -169 C/T polymorphism and systemic lupus erythematosus: a meta-analysis

[PMID 24117236] The Fc receptor-like 3 gene polymorphisms and susceptibility to autoimmune diseases: An updated meta-analysis

[PMID 23564408] The FCRL3 -169T>C polymorphism might be associated with some autoantibody presence in patients with SLE in a Polish population.

[PMID 26051414] FCRL3 gene polymorphisms confer risk for sudden sensorineural hearing loss in a Chinese Han Population

[PMID 25566937OA-icon.png] A genetic study on C5-TRAF1 and progression of joint damage in rheumatoid arthritis