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rs76992529(A;G)

From SNPedia

TTR-related cardiac amyloidosis
Is agenotype
ofrs76992529
GeneTTR
Chromosome18
Position31,598,655
Merged fromRs28933980
mentionedby
Magnitude5
ReputeBad
Geno Mag Summary
(A;A) 5 TTR-related cardiac amyloidosis
(A;G) 5 TTR-related cardiac amyloidosis
(G;G) 0 common in clinvar

A person with one or two copies of the (A) allele of this SNP is at significantly higher (by about 2 - 3 fold) risk of developing cardiac amyloidosis, in which levels of the transthyretin protein build up and may lead to heart failure, especially with increasing age.