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rs7903146(T;T)

From SNPedia

2x increased risk for Type-2 diabetes
Is agenotype
ofrs7903146
GeneTCF7L2
Chromosome10
Position112,998,590
mentionedby
Magnitude3.5
ReputeBad
Geno Mag Summary
(C;C) 2 Normal (lower) risk of Type 2 Diabetes and Gestational Diabetes.
(C;T) 2.1 1.4x increased risk for diabetes (and perhaps colon cancer).
(T;T) 3.5 2x increased risk for Type-2 diabetes

This genotype doubles the risk of Type-2 diabetes, [PMID 17671651] and also Gestational Diabetes. Also increased risk of colo-rectal cancer. Reduced insulin secretion in the pancreas. This has been confirmed in most races. In African Americans it even affects young people.