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SHBG

From SNPedia

is agene
is mentioned by
Full namesex hormone-binding globulin
EntrezGene6462
PheGenI6462
VariationViewer6462
ClinVarSHBG
GeneCardsSHBG
dbSNP6462
SADR6462
HugeNav6462
wikipediaSHBG
googleSHBG
gopubmedSHBG
EVSSHBG
HEFalMpSHBG
MyGene2SHBG
23andMeSHBG
UniProtP04278
EnsemblENSG00000129214
OMIM182205
# SNPs7
 Max MagnitudeChromosome positionSummary
rs121506607,618,597
rs17999411.57,630,105
rs625707,630,399
rs625807,631,360
rs625907,633,209
rs7274287,634,474
rs8585187,629,707

Sex-hormone binding globulin (SHBG) is produced largely in the liver but also in other organs to a minor extent. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable. Polymorphisms in the SHBG gene, such as Rs1799941 have been associated with levels of circulating steroid hormones. Abnormally low or high levels of SHBG have been linked to a number of conditions, including obesity, type II diabetes and infertility.

SNPs in SHBG:


Literature:

[PMID 19574343] Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3)

[PMID 19064566] Identification of common variants in the SHBG gene affecting sex hormone-binding globulin levels and breast cancer risk in postmenopausal women

[PMID 9435448] Human variant sex hormone-binding globulin (SHBG) with an additional carbohydrate chain has a reduced clearance rate in rabbit