rs2014307
From SNPedia
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | increased risk of age-related macular degeneration |
| Make rs2014307(A;C) |
| Make rs2014307(C;C) |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 122458116 |
| Gene | LOC105378525 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2014307 |
| dbSNP (classic) | rs2014307 |
| ClinGen | rs2014307 |
| ebi | rs2014307 |
| HLI | rs2014307 |
| Exac | rs2014307 |
| Gnomad | rs2014307 |
| Varsome | rs2014307 |
| LitVar | rs2014307 |
| Map | rs2014307 |
| PheGenI | rs2014307 |
| Biobank | rs2014307 |
| 1000 genomes | rs2014307 |
| hgdp | rs2014307 |
| ensembl | rs2014307 |
| geneview | rs2014307 |
| scholar | rs2014307 |
| rs2014307 | |
| pharmgkb | rs2014307 |
| gwascentral | rs2014307 |
| openSNP | rs2014307 |
| 23andMe | rs2014307 |
| SNPshot | rs2014307 |
| SNPdbe | rs2014307 |
| MSV3d | rs2014307 |
| GWAS Ctlg | rs2014307 |
| GMAF | 0.3641 |
| Max Magnitude | 0 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
rs572515 was the most significantly associated with AMD risk (P <10-6).
rs9288410 and rs2014307 (PLEKHA1/HTRA1) on 10q26 were significantly associated with AMD status (P= .03 and P <10-6 respectively). After controlling for smoking history, gender and age, the most significant gene-gene interaction appears to be between rs10801575 (CFH) and rs2014307 (PLEKHA1/HTRA1) (P <10-11).
[PMID 18541031
] The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration.
