| Geno
|
Mag
|
Summary
|
| (C;C)
|
1.2
|
slight increase in testicular cancer risk for men
|
| (C;T)
|
1.1
|
slight increase in testicular cancer risk for men
|
| (T;T)
|
0
|
normal
|
Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 40% per copy of the major allele (C) at rs4324715 and rs6897876 (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4 SPRY4 gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene.[PMID 19483682
]
]
