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From SNPedia
Magnitude 3.5
Repute Bad
Summary 2x risk of Alzheimer's disease
Criteria Gs141/criteria

You carry one APOE-ε3 allele and one APOE-ε4 allele. This results in 2x-3x increased relative risk of Alzheimer's disease compared to those carrying two APOE-ε3 alleles. For non-Caucasians the risk is increased, but SNPedia has not yet seen any reliable estimates.

This is based on


Learning while you are healthy that your odds of developing Alzheimer's may be higher than average by the time you are 80 years old can be a shock. Some of the people who have learned about their higher risk have formed ApoE4.info, a non-profit for ApoE4 carriers to discuss research and provide support. This includes a research wiki and a discussion forum.

Genoset gs216 identifies carriers of two ApoE-ε4 alleles.