Gs196

Gs196
Magnitude	1.6
Repute
Summary	Haplogroup I (Y-DNA); 50% higher age-adjusted risk of coronary artery disease?
Criteria	Gs196/criteria

All available markers match for Haplogroup I (Y-DNA).

This haplogroup has subclades under it. The most specific subclade match is the most significant.

The criteria checks up to five different markers of which you must have the mutation defining this haplogroup for each marker you have results for. You must have matching results for at least one marker.

Only one match is required because not every service tests for all markers or your results may have a no-call for a marker. Any one marker should be a reliable indication of the haplogroup. To prevent false positives it also makes sure you do not have the non-mutated variant in all markers for which you have results.

A study of 3,000+ British men concluded that carriers of haplogroup I had about a 50% higher age-adjusted risk of coronary artery disease than did men with other Y haplogroups (for the combined populations, with an odds ratio of 1.56, CI:1.24—1.97, p=0·0002). The association between haplogroup I and coronary artery disease was independent of traditional cardiovascular and socioeconomic risk factors.[PMID 22325189]