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From SNPedia
Magnitude 3.0
Repute Good
Summary Lower heart attack risk than average
Criteria Gs291/criteria

This genoset is reported as having 0.35x the risk of a heart attack or cardiovascular incident compared to people who carry zero of the minor alleles for these two SNPs, based on a study of 3,000 African-Americans enrolled in the Jackson Heart Study.[PMID 25326128]

It is based on alleles at two SNPs, rs1108580 and rs1611115. For European and African populations this is found in roughly 10 - 20 % of people. For east asian populations the frequency is higher.