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From SNPedia
Magnitude 2
Repute Bad
Summary Iron overload may contribute to increased risk of Alzheimer's disease
Criteria Gs294/criteria

rs1799945 H63D and rs1130459 -2G/A

HFE 63HH × TF -2AA synergy factor = 2.0 (1.3–3.05; 0.002) for Northern Europeans

However, HFE 63HH might be associated with higher age of onset for AD. [PMID 20817350]