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From SNPedia
Magnitude 6.5
Repute Bad
Summary Poor metabolizer of fluoropyrimidines (e.g. 5-fluorouracil, capecitabine or tegafur).
Criteria Gs306/criteria

This genoset predicts the presence of two DPYD gene mutations associated with nonfunctional alleles, and therefore greatly increased toxicity if administered chemotherapeutic fluoropyridimines such as 5-fluorouracil and capecitabine. Patients with this genoset are at high risk according to the FDA of toxic (even lethal) reactions and should avoid these drugs.