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From SNPedia

Methadone is the generic name for a synthetic opioid, used medically as an analgesic, antitussive and a maintenance anti-addictive for use in patients on opioids. Trade names include Dolophine, Amidone, Methadose, Physeptone, Heptadon and many others); for more information about methadone, see the Wikipedia page.

SNPs may affect the efficacy and thus optimal dose of methadone when used to kick a heroin or other opiate addiction, such as:

  • Near the OPRM1 gene, encoding the μ-opioid receptor which methadone acts as a selective agonist at:
    • rs73568641, reported specific to African-Americans