Methadone is the generic name for a synthetic opioid, used medically as an analgesic, antitussive and a maintenance anti-addictive for use in patients on opioids. Trade names include Dolophine, Amidone, Methadose, Physeptone, Heptadon and many others); for more information about methadone, see the Wikipedia page.
SNPs may affect the efficacy and thus optimal dose of methadone when used to kick a heroin or other opiate addiction, such as:
- In the ABCB1 gene, encoding the protein for which methadone is one substrate:
- Near the OPRM1 gene, encoding the μ-opioid receptor which methadone acts as a selective agonist at:
- rs73568641, reported specific to African-Americans