rs1042173
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | normal | |
| (G;T) | normal | |
| (T;T) | 0 | among alcoholics, likely to be heavier drinkers |
| Reference | GRCh38 38.1/141 |
| Chromosome | 17 |
| Position | 30197993 |
| Gene | SLC6A4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1042173 |
| dbSNP (classic) | rs1042173 |
| ClinGen | rs1042173 |
| ebi | rs1042173 |
| HLI | rs1042173 |
| Exac | rs1042173 |
| Gnomad | rs1042173 |
| Varsome | rs1042173 |
| LitVar | rs1042173 |
| Map | rs1042173 |
| PheGenI | rs1042173 |
| Biobank | rs1042173 |
| 1000 genomes | rs1042173 |
| hgdp | rs1042173 |
| ensembl | rs1042173 |
| geneview | rs1042173 |
| scholar | rs1042173 |
| rs1042173 | |
| pharmgkb | rs1042173 |
| gwascentral | rs1042173 |
| openSNP | rs1042173 |
| 23andMe | rs1042173 |
| SNPshot | rs1042173 |
| SNPdbe | rs1042173 |
| MSV3d | rs1042173 |
| GWAS Ctlg | rs1042173 |
| GMAF | 0.494 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs1042173 is a SNP in the solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 SLC6A4 gene.
A study of 275 patients seeking treatment for alcoholism concluded that Caucasians of with the rs1042173(T;T) genotype consumed an average of 11.17 drinks per drinking day, compared with an average of 8.58 for carriers of a rs1042173(G) allele (p = 0.0034). While this held true for both men and women, this association was not seen in Hispanics. [PMID 19032574
]
[PMID 21247998] Pharmacogenetic Approach at the Serotonin Transporter Gene as a Method of Reducing the Severity of Alcohol Drinking
[PMID 21585624] Association of haplotype combination of serotonin transporter gene polymorphisms with monthly headache days in MOH patients
[PMID 22355291] Preliminary Evidence for cue-induced Alcohol Craving Modulated by Serotonin Transporter Gene Polymorphism rs1042173.
[PMID 15361494] Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women.
[PMID 17999363] Multifactor dimensionality reduction-phenomics: a novel method to capture genetic heterogeneity with use of phenotypic variables.
[PMID 18486105] New evidence for the association of the serotonin transporter gene (SLC6A4) haplotypes, threatening life events, and depressive phenotype.
[PMID 19141529] Serotonin transporter polymorphisms in patients with portopulmonary hypertension.
[PMID 19199283] Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples.
[PMID 20395645] Association study of serotonin transporter gene (SLC6A4) in systemic sclerosis in European Caucasian populations.
[PMID 21290142] Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour.
[PMID 23484320] [Relationship between genetic polymorphisms of 3 SNP loci in 5-HTT gene and paranoid schizophrenia]
[PMID 23558235] Independent effects of 5' and 3' functional variants in the serotonin transporter gene on suicidal behavior in the context of childhood trauma
[PMID 23757001] Association, interaction, and replication analysis of genes encoding serotonin transporter and 5-HT3 receptor subunits A and B in alcohol dependence
[PMID 23290502] Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers
[PMID 22727904] Sex determines which section of the SLC6A4 gene is linked to obsessive-compulsive symptoms in normal Chinese college students.
| ClinVar | |
|---|---|
| Risk | Rs1042173(G;G) |
| Alt | Rs1042173(G;G) |
| Reference | Rs1042173(T;T) |
| Significance | Probable-non-pathogenic |
| Disease | Behavior disorder |
| Variation | info |
| Gene | SLC6A4 |
| CLNDBN | Behavior disorder |
| Reversed | 1 |
| HGVS | NC_000017.10:g.28525011A>C |
| CLNSRC | |
| CLNACC | RCV000308551.1, |
