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From SNPedia

Geno Mag Summary
(A;A) 0 common/normal
(A;G) 2 1,51x increased Coronary Heart disease risk
(G;G) 3 2,57x increased Coronary Heart disease risk
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs10455872
1000 genomesrs10455872
GWAS Ctlgrs10455872
Max Magnitude3
? (A;A) (A;G) (G;G) 28

[PMID 20032323] Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease rs10455872, was associated with about 1.5-fold increased risk of Coronary Heart Disease. celera

[PMID 20160194] Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians

[PMID 20605575] Single variants can explain the association between coronary heart disease and haplotypes in the apolipoprotein(a) locus


[PMID 21900290OA-icon.png] Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes

[PMID 22368281OA-icon.png] Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: Importance of Lp(a).

GWAS snp
PMID [PMID 22331829]
Title Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.
Risk Allele
P-val 5E-15
Odds Ratio 6.8000 None

[PMID 21127300OA-icon.png] Genetic variation in LPAL2, LPA, and PLG predicts plasma lipoprotein(a) level and carotid artery disease risk.

[PMID 21252144] Lipoprotein(a) genetic variants associated with coronary and peripheral vascular disease but not with stroke risk in the Heart Protection Study.

[PMID 21283670OA-icon.png] Single-nucleotide polymorphisms in LPA explain most of the ancestry-specific variation in Lp(a) levels in African Americans.

[PMID 21305047OA-icon.png] Variation in LPA is associated with Lp(a) levels in three populations from the Third National Health and Nutrition Examination Survey.

[PMID 22560621] Cost-effectiveness model of use of genetic testing as an aid in assessing the likely benefit of aspirin therapy for primary prevention of cardiovascular disease.

GWAS snp
PMID [PMID 23118302]
Trait Lipoprotein-associated phospholipase A2 activity change in response to statin therapy
Title Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.
Risk Allele G
P-val 2E-16
Odds Ratio 4.80 [0.82-2.78] percent increase

[PMID 23735648] Validation and Quantification of Genetic Determinants of Lipoprotein-a Levels and Predictive Value for Angiographic Coronary Artery Disease

[PMID 23978127OA-icon.png] Lack of association between lipoprotein(a) genetic variants and subsequent cardiovascular events in Chinese Han patients with coronary artery disease after percutaneous coronary intervention

[PMID 24161338] Elevated Lipoprotein(a) and Risk of Aortic Valve Stenosis in the General Population

GWAS snp
PMID [PMID 23388002OA-icon.png]
Trait Aortic-valve calcification
Title Genetic associations with valvular calcification and aortic stenosis.
Risk Allele G
P-val 3E-11
Odds Ratio 2.05 [1.66-2.53]

[PMID 24622370] Lipoprotein(a) concentrations, isoform size, and risk of type 2 diabetes: a Mendelian randomisation study

[PMID 22898070] Apolipoprotein(a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism.

[PMID 23100282OA-icon.png] Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

[PMID 23278389] Two rare variants explain association with acute myocardial infarction in an extended genomic region including the apolipoprotein(A) gene.

[PMID 23375930] Extreme lipoprotein(a) levels and improved cardiovascular risk prediction.

[PMID 24776095OA-icon.png] LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography

[PMID 24903972] Genetic predisposition to calcific aortic stenosis and mitral annular calcification

GWAS snp
PMID [PMID 24262325OA-icon.png]
Trait Coronary artery disease or ischemic stroke
Title Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
Risk Allele
P-val 2E-12
Odds Ratio NR NR

[PMID 24760552OA-icon.png] Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts

[PMID 26564469] Advances in the Association between Apolipoprotein(a)Gene Polymorphisms and Coronary Heart Disease

Risk Rs10455872(G;G)
Alt Rs10455872(G;G)
Reference Rs10455872(A;A)
Significance Drug-response
Disease HMG CoA reductase inhibitors response - Efficacy
Variation info
Gene LPA
CLNDBN HMG CoA reductase inhibitors response - Efficacy
Reversed 0
HGVS NC_000006.11:g.161010118A>G
CLNSRC PharmGKB Clinical Annotation
CLNACC RCV000211156.1,

[PMID 27831500OA-icon.png] The LPA Gene, Ethnicity, and Cardiovascular Events.

[PMID 28566218OA-icon.png] Relations between lipoprotein(a) concentrations, LPA genetic variants, and the risk of mortality in patients with established coronary heart disease: a molecular and genetic association study.

[PMID 29703846OA-icon.png] LPA Variants are Associated with Residual Cardiovascular Risk in Patients Receiving Statins.

[PMID 30594920] Investigation of LPA sequence variants rs6415084, rs3798220 with conventional coronary artery disease in Iranian CAD patients.

[PMID 30759150OA-icon.png] Using topic modeling via non-negative matrix factorization to identify relationships between genetic variants and disease phenotypes: A case study of Lipoprotein(a) (LPA).

[PMID 32152647OA-icon.png] Lipoprotein(a) plasma levels are not associated with incident microvascular complications in type 2 diabetes mellitus.

[PMID 32220223OA-icon.png] Association between lipoprotein(a) (Lp(a)) levels and Lp(a) genetic variants with coronary artery calcification.

[PMID 32343731OA-icon.png] A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.