rs10468017

plus

Geno	Mag	Summary
(C;T)	2	associated with higher HDL cholesterol
(T;T)	2	associated with higher HDL cholesterol

Make rs10468017(C;C)

Reference

GRCh38 38.1/141

Chromosome

15

Position

58386313

Gene	LOC101928635

is a	snp
is	mentioned by
dbSNP	rs10468017
dbSNP (classic)	rs10468017
ClinGen	rs10468017
ebi	rs10468017
HLI	rs10468017
Exac	rs10468017
Gnomad	rs10468017
Varsome	rs10468017
LitVar	rs10468017
Map	rs10468017
PheGenI	rs10468017
Biobank	rs10468017
1000 genomes	rs10468017
hgdp	rs10468017
ensembl	rs10468017
geneview	rs10468017
scholar	rs10468017
google	rs10468017
pharmgkb	rs10468017
gwascentral	rs10468017
openSNP	rs10468017
23andMe	rs10468017
SNPshot	rs10468017
SNPdbe	rs10468017
MSV3d	rs10468017
GWAS Ctlg	rs10468017

GMAF

0.2094

Max Magnitude

2

?

(C;C) (C;T) (T;T)

28

GWAS snp
PMID	[PMID 19060906 ]
Trait	HDL cholesterol
Title	Common variants at 30 loci contribute to polygenic dyslipidemia
Risk Allele	T
P-val	8E-23
Odds Ratio	0.10 [0.06-0.14] SD increase

T allele is associated with 1.76mg/dl increase in HDL cholesterol (good cholesterol). [PMID 18193043 ]

[PMID 20385826 ] Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)

[PMID 21139980 ] Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration

GWAS snp
PMID	[PMID 21386085 ]
Trait
Title	A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
Risk Allele	C
P-val	6E-8
Odds Ratio	0.1600 [0.10-0.22] unit increase

GWAS snp
PMID	[PMID 21665990 ]
Trait
Title	Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
Risk Allele
P-val	3E-12
Odds Ratio	1.1900 [NR]

[PMID 22247473 ] Prospective Assessment of Genetic Effects on Progression to Different Stages of Age-related Macular Degeneration Using Multi-state Markov Models

GWAS snp
PMID	[PMID 21943158 ]
Trait
Title	Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.
Risk Allele	T
P-val	3E-12
Odds Ratio	0.1040 [0.075-0.133] mmol/l increase

GWAS snp
PMID	[PMID 22359512 ]
Trait
Title	Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
Risk Allele
P-val	7E-43
Odds Ratio	0 None

[PMID 19951432 ] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20160193 ] Investigation of variants identified in caucasian genome-wide association studies for plasma high-density lipoprotein cholesterol and triglycerides levels in Mexican dyslipidemic study samples.

[PMID 20385819 ] Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

[PMID 24223199 ] Association of HDL-Related Loci with Age-Related Macular Degeneration and Plasma Lutein and Zeaxanthin: the Alienor Study

[PMID 22692312] [Mendelian randomization study of the relationship between high-density lipoprotein cholesterol and age-related macular degeneration].

[PMID 23348725 ] Association of LIPC and advanced age-related macular degeneration.

[PMID 25010633] The Relationship Between Hepatic Lipase Gene Variant and Advanced Age-Related Macular Degeneration: A Meta-analysis

GWAS snp
PMID	[PMID 24816252 ]
Trait	Blood metabolite levels
Title	An atlas of genetic influences on human blood metabolites.
Risk Allele	T
P-val	3E-12
Odds Ratio	.02 [0.013-0.025] unit increase

[PMID 27099955 ] Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials.

[PMID 29259020 ] Genetic risk factors for late age-related macular degeneration in India.

[PMID 31910446 ] Genome-wide association study of metabolic syndrome in Korean populations.