rs10524523

plus

Geno	Mag	Summary
(-;-)	1.5	lower risk of late-onset Alzheimer's disease
(TTTTTTTTTTTTTTTTTTT;TTTTTTTTTTTTTTTTTTT)	3	higher risk for late-onset Alzheimer's disease

Make rs10524523(-;TTTTTTTTTTTTTTTTTTT)

Reference

GRCh38 38.1/142

Chromosome

19

Position

44899792

Gene

TOMM40

is a	snp
is	mentioned by
dbSNP	rs10524523
dbSNP (classic)	rs10524523
ClinGen	rs10524523
ebi	rs10524523
HLI	rs10524523
Exac	rs10524523
Gnomad	rs10524523
Varsome	rs10524523
LitVar	rs10524523
Map	rs10524523
PheGenI	rs10524523
Biobank	rs10524523
1000 genomes	rs10524523
hgdp	rs10524523
ensembl	rs10524523
geneview	rs10524523
scholar	rs10524523
google	rs10524523
pharmgkb	rs10524523
gwascentral	rs10524523
openSNP	rs10524523
23andMe	rs10524523
SNPshot	rs10524523
SNPdbe	rs10524523
MSV3d	rs10524523
GWAS Ctlg	rs10524523

Status

Deleted

Max Magnitude

3

Alzheimer's disease

[PMID 20029386 ] A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease

[PMID 21263443] APOE E4 status predicts age-related cognitive decline in the ninth decade: longitudinal follow-up of the Lothian Birth Cohort 1921

[PMID 21825236 ] Association and Expression Analyses With Single-Nucleotide Polymorphisms in TOMM40 in Alzheimer Disease

[PMID 22008263] TOMM40 rs10524523 Polymorphism's Role in Late-Onset Alzheimer's Disease and in Longevity

[PMID 22359560 ] Characterization of the Poly-T Variant in the TOMM40 Gene in Diverse Populations

[PMID 22596268] Biochemical Studies of Poly-T Variants in the Alzheimer's Disease Associated TOMM40 Gene [PMID 20457951 ] An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.

[PMID 24103330] Polymorphism in the TOMM40 gene modifies the risk of developing sporadic inclusion body myositis and the age of onset of symptoms [PMID 22863908 ] A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

[PMID 23792692] Role of TOMM40 rs10524523 polymorphism in onset of alzheimer's disease caused by the PSEN1 M146L mutation.

[PMID 25862420] The effect of TOMM40 on spatial navigation in amnestic mild cognitive impairment