Geno
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Mag
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Summary
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(A;A)
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0
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1.5x risk of Crohn's disease
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(A;G)
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1
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1.2x risk of Crohn's disease
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(G;G)
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0
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normal
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rs10761659 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.23 (CI 1.05-1.45), and for homozygotes, 1.55 (CI 1.3-1.84). [PMID 17554300]
[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
OMIM | 612255 |
Desc | INFLAMMATORY BOWEL DISEASE 15; IBD15 |
Variant | |
Related | also |
GWAS snp
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PMID
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[PMID 21102463]
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Trait
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Title
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
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Risk Allele
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G
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P-val
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4E-22
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Odds Ratio
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1.2300 [1.18-1.29]
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[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 18936107] Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.
[PMID 20846217] Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
GWAS snp
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PMID
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[PMID 22936669]
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Trait
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Crohn's disease
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Title
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A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
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Risk Allele
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G
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P-val
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5E-6
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Odds Ratio
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1.28 [NR]
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