rs10923931
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common in complete genomics |
| Make rs10923931(G;T) |
| Make rs10923931(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 119975336 |
| Gene | NOTCH2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10923931 |
| dbSNP (classic) | rs10923931 |
| ClinGen | rs10923931 |
| ebi | rs10923931 |
| HLI | rs10923931 |
| Exac | rs10923931 |
| Gnomad | rs10923931 |
| Varsome | rs10923931 |
| LitVar | rs10923931 |
| Map | rs10923931 |
| PheGenI | rs10923931 |
| Biobank | rs10923931 |
| 1000 genomes | rs10923931 |
| hgdp | rs10923931 |
| ensembl | rs10923931 |
| geneview | rs10923931 |
| scholar | rs10923931 |
| rs10923931 | |
| pharmgkb | rs10923931 |
| gwascentral | rs10923931 |
| openSNP | rs10923931 |
| 23andMe | rs10923931 |
| SNPshot | rs10923931 |
| SNPdbe | rs10923931 |
| MSV3d | rs10923931 |
| GWAS Ctlg | rs10923931 |
| GMAF | 0.1524 |
| Max Magnitude | 0 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 18372903 ]
|
| Trait | Type 2 diabetes |
| Title | Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes |
| Risk Allele | T |
| P-val | 4.0000000000000001E-8 |
| Odds Ratio | 1.13 [1.08-1.17] |
[PMID 19455301] Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals
[PMID 19789630] Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study
[PMID 21421807] In a study conducted on 6,580 Nondiabetic Finnish Men, rs10923931 in NOTCH2 gene showed nominal or significant associations with several lipoprotein traits.
[PMID 22052079] Association analysis of 31 common polymorphisms with type 2 diabetes and its related traits in Indian sib pairs
[PMID 18567820] Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.
[PMID 18694974] Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
[PMID 18714373] Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.
[PMID 18782870] Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
[PMID 18852197] Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
[PMID 19020323] Genotype score in addition to common risk factors for prediction of type 2 diabetes.
[PMID 19096518] Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
[PMID 19207020] Meta-analysis in genome-wide association studies.
[PMID 19324937] Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
[PMID 19401414] Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.
[PMID 19460916] Genetic architecture of type 2 diabetes: recent progress and clinical implications.
[PMID 19502414] Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
[PMID 19526209] Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
[PMID 19602701] Underlying genetic models of inheritance in established type 2 diabetes associations.
[PMID 19639606] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 19956539] How many genetic variants remain to be discovered?
[PMID 20043853] Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
[PMID 20075150] Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
[PMID 20144327] A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
[PMID 20482849] NOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21278902] Genetic risk profiling for prediction of type 2 diabetes.
[PMID 22237986] Genetic susceptibility to type 2 diabetes and breast cancer risk in women of European and African ancestry.
[PMID 22377712] Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
[PMID 23334806] Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
[PMID 23462794] Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
