rs11031006

plus

Geno	Mag	Summary
(A;A)	1.5	slightly lower odds of giving birth to fraternal twins
(A;G)	1.5	slightly lower odds of giving birth to fraternal twins
(G;G)	1.5	Most common genotype; slightly higher odds of giving birth to fraternal twins

Reference

GRCh38.p2 38.2/147

Chromosome

11

Position

30204981

Gene	LOC105376607

is a	snp
is	mentioned by
dbSNP	rs11031006
dbSNP (classic)	rs11031006
ClinGen	rs11031006
ebi	rs11031006
HLI	rs11031006
Exac	rs11031006
Gnomad	rs11031006
Varsome	rs11031006
LitVar	rs11031006
Map	rs11031006
PheGenI	rs11031006
Biobank	rs11031006
1000 genomes	rs11031006
hgdp	rs11031006
ensembl	rs11031006
geneview	rs11031006
scholar	rs11031006
google	rs11031006
pharmgkb	rs11031006
gwascentral	rs11031006
openSNP	rs11031006
23andMe	rs11031006
SNPshot	rs11031006
SNPdbe	rs11031006
MSV3d	rs11031006
GWAS Ctlg	rs11031006

Max Magnitude

1.5

?

(A;A) (A;G) (G;G)

28

A meta-analysis found that the most common allele for this SNP, rs11031006(G), is actually associated with a slightly higher likelihood of giving birth to fraternal (dizygotic) twins (odds ratio 1.41, CI:1.29–1.53, p= 1.54 × 10e−9) compared to carriers of the (A) allele. A subsequent replication study of Icelanders yielded lower odds (1.14, CI:1.06–1.22,p=3 × 10e−3).

[PMID 27406421] Two SNPs Associated With Spontaneous Dizygotic Twinning: Effect Sizes and How We Communicate Them.

[PMID 27132594 ] Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.

[PMID 28901453 ] The role of gene polymorphisms in endometriosis.

[PMID 30843750] Genetic variants linked to folliculogenesis and successful pregnancy are not associated with twin births in a twins' town.

[PMID 32143537 ] Genetic Characterization of Endometriosis Patients: Review of the Literature and a Prospective Cohort Study on a Mediterranean Population.