||1.7x increased risk for neuroblastoma
||1.3x increased risk for neuroblastoma
rs110419 is a SNP in the LMO1 LIM domain only 1 (rhombotin 1) gene.
A GWAS study of 2,000+ patients (and 6,000+ controls) concluded that the rs110419(A) allele is associated with increased risk for neuroblastoma, with an allelic odds ratio of 1.34 (CI: 1.25 - 1.44, combined p = 5.2 x 10e-16).[PMID 21124317]
|?|| (A;A) (A;G) (G;G) ||28|
[PMID 18463370] Chromosome 6p22 locus associated with clinically aggressive neuroblastoma.
||Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.