|(C;T)||1.5||0.84x decreased risk for Alzheimer's disease|
|(T;T)||1.5||0.84x decreased risk for Alzheimer's disease|
A study of over 5,000 Alzheimer's disease patients (and over 10,000 controls) found a slight protective effect of the (T) allele of this SNP. rs11136000(T) carriers had a slightly decreased risk for Alzheimer's disease, with an odds ratio of 0.84 (CI: 0.8-0.9, p=1.4x10e-9).10.1038/ng.440
[PMID 21543606] A MRI study of ~400 young (average age: 23) healthy carriers of rs11136000(C) alleles found a distinct profile of lower white matter integrity in these individuals that may increase their vulnerability to developing Alzheimer's later in life. To put it another way, 50 years before the actual development of Alzheimer's, most of us - after all, the (C) allele is the common one - apparently show some evidence of weakness in myelin, the protective covering around the neuron’s axons in the brain, (slightly) predisposing us to late-onset Alzheimer’s, at least compared to carriers of one or two (T) alleles.
|Title||Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease|
|Odds Ratio||1.16 [1.11-1.22]|
[PMID 19734903] Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
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[PMID 20209083] Genetic variability in CLU and its association with Alzheimer's disease.
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[PMID 20738160] Association analysis between the rs11136000 single nucleotide polymorphism in clusterin gene, rs3851179 single nucleotide polymorphism in clathrin assembly lymphoid myeloid protein gene and the patients with schizophrenia in the Chinese population.
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[PMID 21397462] Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene.
[PMID 21422520] Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration.
[PMID 21726919] CR1 genotype is associated with entorhinal cortex volume in young healthy adults.
[PMID 22015308] Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population.
[PMID 22402018] Implication of common and disease specific variants in CLU, CR1, and PICALM
[PMID 23419238] Allele-specific polymerase chain reaction for the detection of Alzheimer's disease-related single nucleotide polymorphisms
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[PMID 25051234] Intracellular Clusterin Interacts with Brain Isoforms of the Bridging Integrator 1 and with the Microtubule-Associated Protein Tau in Alzheimer's Disease
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[PMID 27076484] The Association Between Clusterin and APOE Polymorphisms and Late-Onset Alzheimer Disease in a Turkish Cohort
[PMID 28316001] Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance.
[PMID 28567584] rs3851179 Polymorphism at 5' to the PICALM Gene is Associated with Alzheimer and Parkinson Diseases in Brazilian Population.