rs1126742
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | normal | |
| (C;T) | higher hypertension risk | |
| (T;T) | 0 | higher hypertension risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 46932824 |
| Gene | CYP4A11 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1126742 |
| dbSNP (classic) | rs1126742 |
| ClinGen | rs1126742 |
| ebi | rs1126742 |
| HLI | rs1126742 |
| Exac | rs1126742 |
| Gnomad | rs1126742 |
| Varsome | rs1126742 |
| LitVar | rs1126742 |
| Map | rs1126742 |
| PheGenI | rs1126742 |
| Biobank | rs1126742 |
| 1000 genomes | rs1126742 |
| hgdp | rs1126742 |
| ensembl | rs1126742 |
| geneview | rs1126742 |
| scholar | rs1126742 |
| rs1126742 | |
| pharmgkb | rs1126742 |
| gwascentral | rs1126742 |
| openSNP | rs1126742 |
| 23andMe | rs1126742 |
| SNPshot | rs1126742 |
| SNPdbe | rs1126742 |
| MSV3d | rs1126742 |
| GWAS Ctlg | rs1126742 |
| GMAF | 0.174 |
| Max Magnitude | 0 |
rs1126742 is a SNP in the CYP4A11 gene, which encodes an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans.
In a study of 304 Japanese hypertension patients, rs1126742(C;T) and (T;T) genotypes were significantly (p=0.022) higher than in control individuals.[PMID 18300855]
[PMID 18484194] Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject.
[PMID 22327816] A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease.
[PMID 22804341] Haplotype-based case-control study of CYP4A11 gene and myocardial infarction
[PMID 24164311] CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population
[PMID 23085321] Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.
[PMID 28534704] Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population.
