||3-6x higher odds of worse outcomes in breast cancer patients
|?|| (C;C) (C;T) (T;T) ||28|
rs1131532 is a SNP in the tumor necrosis factor superfamily member 10 TNFSF10 gene.
A study of 240 patients with early invasive ductal breast cancer followed for a median of 53 months concluded that rs1131532(T;T) individuals had lower odds of being disease-free or distant-disease free, and for overall survival (hazard ratio 3.304, 4.757, and 6.459; p = 0.002, 0.001, and 0.009, respectively).[PMID 19890662]
[PMID 18778477] Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival.
[PMID 20031590] The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations.