|(C;C)||2.4||0.80x reduced risk for glioblastoma as well a 84% in CAD risk|
|(C;T)||2||0.80x reduced risk for glioblastoma|
A study of 1,000 glioblastoma multiforme cases and 2,000 controls in the US concluded that the PARP1 gene rs1136410(C) allele was associated with a 20% reduction in risk for glioblastoma multiforme (odds ratio 0.80, CI: 0.67-0.95).[PMID 19318434]
A meta-analysis of 21 studies with 12,027 cancer patients found no significant association overall between rs1136410 and cancer risk, however, in the stratified analyses, rs1136410(C) was associated with an increased risk of cancer among Asian populations (CT + CC vs. TT: odds ratio 1.11, CI: 1.01-1.23, p(heterogeneity) = 0.210), but a decreased risk of cancer (CT + CC vs. TT: odds ratio 0.89, CI: 0.80-1.00, p(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (odds ratio 0.79, CI: 0.69-0.90, p(heterogeneity) = 0.800).[PMID 22127734]
A study of 2803 CAD patients and 2840 controls in a Chinese Han population has found a significantly reduced risk of 84% for the rs1136410 GG polymorphism, but without smoking habit, type 2 diabetes mellitus, and hyperlipidemia. This recessive model protection is highly probable explained due to a decrease of PARP activity. Template:PMID=29184509
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