rs11572080
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | >1.81x risk of GI bleeding with NSAID drugs |
| (A;G) | 1.5 | 1.81x risk of GI bleeding with NSAID drugs |
| (G;G) | 1 | No increased risk of GI bleeding on NSAID drugs |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 95067273 |
| Gene | CYP2C8 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11572080 |
| dbSNP (classic) | rs11572080 |
| ClinGen | rs11572080 |
| ebi | rs11572080 |
| HLI | rs11572080 |
| Exac | rs11572080 |
| Gnomad | rs11572080 |
| Varsome | rs11572080 |
| LitVar | rs11572080 |
| Map | rs11572080 |
| PheGenI | rs11572080 |
| Biobank | rs11572080 |
| 1000 genomes | rs11572080 |
| hgdp | rs11572080 |
| ensembl | rs11572080 |
| geneview | rs11572080 |
| scholar | rs11572080 |
| rs11572080 | |
| pharmgkb | rs11572080 |
| gwascentral | rs11572080 |
| openSNP | rs11572080 |
| 23andMe | rs11572080 |
| SNPshot | rs11572080 |
| SNPdbe | rs11572080 |
| MSV3d | rs11572080 |
| GWAS Ctlg | rs11572080 |
| GMAF | 0.06474 |
| Max Magnitude | 2 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
This is a CYP2C8 SNP. The CYP2C8*3 allele is mapped to both rs10509681 and rs11572080).
[PMID 19422321] In a 2009 article titled "Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?" It is claimed that individuals carrying minor alleles of this SNP (usually heterozygotes, since minor homozygotes are rare) may show increased risk of developing acute gastrointestinal bleeding during the use of NSAIDs that are CYP2C8 or CYP2C9 substrates, such as aceclofenac, celecoxib, diclofenac, ibuprofen, indomethazine, lornoxicam, meloxicam, naproxen, piroxicam, tenoxicam and valdecoxib.
[PMID 18216720] In a 2008 article (reviewed in [PMID 19422321]) titled "Interaction of CYP2C8 and CYP2C9 genotypes modifies the risk for nonsteroidal anti-inflammatory drugs-related acute gastrointestinal bleeding," the study discovered that carriers of CYP2C8*3 (a minor allele of both rs10509681 and rs11572080) had a GI bleeding event risk OR=1.81 (95% CI=0.95–3.46; P=0.071) and risk increased if carriers drank more than 20g alcohol/day to an OR=1.99 (95% CI=1.06–3.74; P=0.034). As CYP2C8*3 and CYP2C9*2 rs1799853 variant alleles are in linkage disequilibrium, patients are likely to carry the risk allele to both 8*3 and 9*2, and when they do, The OR (95% CI) for carriers of such a genotype is increased to 1.94 (1.13–3.33), P=0.017.
[PMID 16385451
] A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
[PMID 17048007] Association of warfarin dose with genes involved in its action and metabolism.
[PMID 18303964] Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids.
[PMID 18769365] Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
[PMID 19761371] Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.
[PMID 20808793] Are cytochrome P450 CYP2C8 and CYP2C9 polymorphisms associated with ibuprofen response in very preterm infants?
[PMID 23267857] CYP2C19*17 Gain-of-Function Polymorphism Is Associated With Peptic Ulcer Disease
[PMID 23420707] Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk
[PMID 23133420] Pharmacogenomic Diversity among Brazilians: Influence of Ancestry, Self-Reported Color, and Geographical Origin.
[PMID 23426382] The role of genetic variants in CYP2C8, LPIN1, PPARGC1A and PPARgamma on the trough steady-state plasma concentrations of rosiglitazone and on glycosylated haemoglobin A1c in type 2 diabetes.
