rs11833579 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs12425791.
Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. 10.1056/NEJMoa0900094
[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population
[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population
[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
[PMID 22212150] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan
[PMID 22429733] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions
[PMID 19369658] Genomewide association studies of stroke.
[PMID 20448654] Association study of the polymorphisms on chromosome 12p13 with atherothrombotic stroke in the Japanese population.
[PMID 20957003] [Strong association between the NINJ2 gene polymorphism and the susceptibility of stroke in Chinese Han population in Fangshan district].
[PMID 21376321] No evidence for association of 12p13 SNPs rs11833579 and rs12425791 within NINJ2 gene with ischemic stroke in Chinese Han population.
[PMID 22297388] Association between 12p13 SNPs rs11833579/rs12425791 near NINJ2 gene and ischemic stroke in East Asian population: evidence from a meta-analysis.
[PMID 23270316] Association between the Single Nucleotide Polymorphism rs12425791 and Ischemic Stroke in Chinese Populations: New Data and Meta-analysis
[PMID 22938733] Lack of association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Uyghur population
[PMID 22795341] The rs11833579 and rs12425791 polymorphisms and risk of ischemic stroke in an Asian population: a meta-analysis.
[PMID 25096477] Association between 12p13 SNP rs11833579 and ischemic stroke in Asian population: An updated meta-analysis
[PMID 26312640] Impact of chromosome 12p13 variants on ischemic stroke risk
[PMID 26687183] A Novel Functional Polymorphism in the NINJ2 Promoter Predicts Risk of Large Artery Atherosclerotic Stroke.