||Increased risk for incident vascular dementia
|?|| (A;A) (A;C) (C;C) ||28|
rs12007229 is located on the X chromosome near the androgen receptor gene.
In a genome-wide association study of 5700 dementia-free individuals, 67 patients developed incident vascular dementia over a mean follow-up time of 9.3±3.2 years. The rs12007229(A) allele was associated with this development (odds ratio 3.7, CI: 2.3-5.8, p = 1.3×10e-8). The association was further confirmed in 2 independent populations (probability value of combined replication samples=0.024).[PMID 22116812]
[PMID 15570555] Systematic evaluation of genetic variation at the androgen receptor locus and risk of prostate cancer in a multiethnic cohort study.
[PMID 27103528] Association of genetic risk factors with cognitive decline: the PATH through life project.