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From SNPedia

Geno Mag Summary
(C;T) 0 common in complete genomics
Make rs1205(C;C)
Make rs1205(T;T)
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1205
1000 genomesrs1205
GWAS Ctlgrs1205
Max Magnitude0
? (C;C) (C;T) (T;T) 28

Although somewhat lacking in statistical power, several reports have linked rs1205, a UTR mutation known as CRP4 in the C-reactive protein CRP to the autoimmune disorder SLE, systemic lupus erythematosus. The risk allele in dbSNP orientation is (T). [PMID 14645206, PMID 15897982]

[PMID 19139754OA-icon.png] C-reactive protein (CRP) levels obesity rs1205(G) allele had significantly higher CRP levels than noncarriers in a dose-dependent manner suggesting a possible association with fat localization

23andMe blog each rs1205(T) lowered CRP by 20% but no association with heart disease.


[PMID 19040303] C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain

[PMID 19433520OA-icon.png] Polymorphisms of the CRP gene inhibit inflammatory response and increase susceptibility to depression: The Health in Men Study


[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity

[PMID 19692124] Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration

[PMID 19821022] Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples

[PMID 19965533OA-icon.png] CRP polymorphisms and progression of chronic kidney disease in African Americans

[PMID 20538124] Genetic Polymorphisms and the Cardiovascular Risk of Non-Steroidal Anti-Inflammatory Drugs

[PMID 20552244] Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia

[PMID 20733302] Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke

[PMID 20333461] Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

[PMID 20856253] Combined effect of C-reactive protein gene SNP +2147 A/G and interleukin-6 receptor gene SNP rs2229238 C/T on anthropometric characteristics among school children in Taiwan

[PMID 20949557OA-icon.png] Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival

[PMID 21293934] Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer


[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey

[PMID 21080913] The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study

[PMID 21575917] C reactive protein and alpha1-antitrypsin: relationship between levels and gene variants

[PMID 22004660OA-icon.png] Genetic Variants, Immune Function, and Risk of Pre-Eclampsia among American Indians

[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16723442OA-icon.png] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

[PMID 16733231] Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

[PMID 17101857] Genetic variation is associated with C-reactive protein levels in the Third National Health and Nutrition Examination Survey.

[PMID 17697822] Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study).

[PMID 17888441OA-icon.png] Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.

[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

[PMID 17903293OA-icon.png] Genome-wide association with select biomarker traits in the Framingham Heart Study.

[PMID 17956875] DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.

[PMID 18000615] Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.

[PMID 18162041OA-icon.png] Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

[PMID 18167554OA-icon.png] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

[PMID 18216863OA-icon.png] Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

[PMID 18285551OA-icon.png] Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

[PMID 18385179] Systemic inflammation, genetic susceptibility and lung function.

[PMID 18394581OA-icon.png] Bayesian meta-analysis of genetic association studies with different sets of markers.

[PMID 18439548OA-icon.png] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

[PMID 18500540OA-icon.png] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

[PMID 18700811OA-icon.png] Inflammation, insulin resistance, and diabetes--Mendelian randomization using CRP haplotypes points upstream.

[PMID 18704199OA-icon.png] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

[PMID 18714381OA-icon.png] Does high C-reactive protein concentration increase atherosclerosis? The Whitehall II Study.

[PMID 18714384OA-icon.png] The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

[PMID 18793001OA-icon.png] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

[PMID 19075099] Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.

[PMID 19076828OA-icon.png] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

[PMID 19095725OA-icon.png] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

[PMID 19262552OA-icon.png] C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

[PMID 19267250OA-icon.png] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

[PMID 19272152OA-icon.png] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

[PMID 19426506OA-icon.png] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

[PMID 19436291OA-icon.png] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

[PMID 19567438OA-icon.png] Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

[PMID 19796676OA-icon.png] Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.

[PMID 19906786OA-icon.png] Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.

[PMID 19962488OA-icon.png] Pleiotropy of C-reactive protein gene polymorphisms with C-reactive protein levels and heart rate variability in healthy male twins.

[PMID 20078877OA-icon.png] Gene polymorphisms in association with emerging cardiovascular risk markers in adult women.

[PMID 20616999OA-icon.png] Usefulness of Mendelian randomization in observational epidemiology.

[PMID 20974458] Maternal C-reactive protein levels in pregnancy are associated with wheezing and lower respiratory tract infections in the offspring.

[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

[PMID 21094359] Effect of central obesity, low high-density lipoprotein cholesterol and C-reactive protein polymorphisms on C-reactive protein levels during treatment with Rosuvastatin (10 mg Daily).

[PMID 21296145OA-icon.png] Association between adolescent emotional problems and metabolic syndrome: the modifying effect of C-reactive protein gene (CRP) polymorphisms.

[PMID 21325005OA-icon.png] Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

[PMID 21647738OA-icon.png] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

[PMID 21790705] The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics.

[PMID 21979869OA-icon.png] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

[PMID 23212764] Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma

[PMID 23254959] Serum C-reactive protein and risk of lung cancer: a case-control study

[PMID 23267696OA-icon.png] Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study

[PMID 23940726OA-icon.png] Two variants of the C-reactive protein gene are associated with risk of pre-eclampsia in an american Indian population

[PMID 24574329] Serum C-reactive protein (CRP) associates with lupus disease activity in the absence of measurable interferon alpha and a CRP gene variant

[PMID 24602049] Association of gene polymorphisms with the risk of warfarin bleeding complications at therapeutic INR in patients with mechanical cardiac valves

[PMID 23397258] Association study of CRP gene in systemic sclerosis in European Caucasian population.

[PMID 24862635] Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)

[PMID 24894103] Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis

[PMID 25025473OA-icon.png] Mutations of C-Reactive Protein (CRP) -286 SNP, APC and p53 in Colorectal Cancer: Implication for a CRP-Wnt Crosstalk

[PMID 25020710] P324Circadian genes in the regulation of lipids in coronary artery disease

[PMID 25043606OA-icon.png] Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

[PMID 25993353] Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

[PMID 25224558OA-icon.png] Association of variants in genes related to the immune response and obesity with BPH in CLUE II

[PMID 26310275] CRP 1846C>T Genetic Polymorphism Is Associated with Lymph Node Metastasis and/or Severe Lymphatic Invasion in Endometrial Cancer

[PMID 26456189] Interaction of SNP in the CRP gene and plasma fatty acid profile in inflammatory pattern: A cross-sectional population-based study

[PMID 26473826OA-icon.png] Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis

[PMID 26550110OA-icon.png] The role of gene variants of the inflammatory markers CRP and TNF-α in cardiovascular heart disease: systematic review and meta-analysis

[PMID 26813132] [Association of single nucleotide polymorphisms of IL-6 gene with longevity in Uyghurs in Xinjiang].

[PMID 27891353OA-icon.png] Association of C-Reactive Protein (rs1205) Gene Polymorphism with Susceptibility to Psoriasis in South Indian Tamils.

[PMID 28287042] Impact of CRP gene and additional gene-smoking interaction on ischemic stroke in a Chinese Han population.

[PMID 29379005OA-icon.png] Association of Single-Nucleotide Polymorphisms of C-Reactive Protein Gene with Susceptibility to Infantile Sepsis in Southern China.

[PMID 29556849] C-reactive protein (CRP) polymorphisms and haplotypes are associated with SLE susceptibility and activity but not with serum CRP levels in Mexican population.

[PMID 31500937] Interplay between the Mediterranean diet and C-reactive protein genetic polymorphisms towards inflammation in adolescents.

[PMID 31692152] Association of plasma C-reactive protein with ischemic stroke: A Mendelian randomization study.

[PMID 32514365OA-icon.png] C-reactive protein gene rs1205 polymorphism is associated with low-grade chronic inflammation in postmenopausal women.

[PMID 33296257] The Genetic Variants -717T>C (rs2794521), 1444G>A (rs1130864), and 1846 C > T (rs1205) of CRP Gene, Their Haplotypes, and Their Association with Serum CRP Levels, Acute Coronary Syndrome, and Diabetes in Patients from Western Mexico.