rs12402521

plus

Geno	Mag	Summary
(G;G)	2	12–15 mmHg higher blood pressure when under stress

Make rs12402521(A;A)

Make rs12402521(A;G)

Reference

GRCh38 38.1/141

Chromosome

1

Position

186453389

Gene	LOC102724919, PDC

is a	snp
is	mentioned by
dbSNP	rs12402521
dbSNP (classic)	rs12402521
ClinGen	rs12402521
ebi	rs12402521
HLI	rs12402521
Exac	rs12402521
Gnomad	rs12402521
Varsome	rs12402521
LitVar	rs12402521
Map	rs12402521
PheGenI	rs12402521
Biobank	rs12402521
1000 genomes	rs12402521
hgdp	rs12402521
ensembl	rs12402521
geneview	rs12402521
scholar	rs12402521
google	rs12402521
pharmgkb	rs12402521
gwascentral	rs12402521
openSNP	rs12402521
23andMe	rs12402521
SNPshot	rs12402521
SNPdbe	rs12402521
MSV3d	rs12402521
GWAS Ctlg	rs12402521

GMAF

0.3632

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

Candidate gene–based association studies in 2 different human populations revealed several SNPs in the PDC gene to be associated with stress-dependent hypertension. Individuals homozygous for the G allele of an intronic PDC SNP (rs12402521) had 12–15 mmHg higher blood pressure than those carrying the A allele.JCI 2009

[PMID 19959875 ] Phosducin influences sympathetic activity and prevents stress-induced hypertension in humans and mice

[PMID 22365573] Phosducin rs12402521 polymorphism predicts development of hypertension in young subjects with overweight or obesity