rs12750834
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (G;G) | 0 | common/normal; better response to valsartan |
| Make rs12750834(A;A) |
| Make rs12750834(A;G) |
| is a | snp |
| is | mentioned by |
| dbSNP | rs12750834 |
| dbSNP (classic) | rs12750834 |
| ClinGen | rs12750834 |
| ebi | rs12750834 |
| HLI | rs12750834 |
| Exac | rs12750834 |
| Gnomad | rs12750834 |
| Varsome | rs12750834 |
| LitVar | rs12750834 |
| Map | rs12750834 |
| PheGenI | rs12750834 |
| Biobank | rs12750834 |
| 1000 genomes | rs12750834 |
| hgdp | rs12750834 |
| ensembl | rs12750834 |
| geneview | rs12750834 |
| scholar | rs12750834 |
| rs12750834 | |
| pharmgkb | rs12750834 |
| gwascentral | rs12750834 |
| openSNP | rs12750834 |
| 23andMe | rs12750834 |
| SNPshot | rs12750834 |
| SNPdbe | rs12750834 |
| MSV3d | rs12750834 |
| GWAS Ctlg | rs12750834 |
| Max Magnitude | 0 |
aka C-3152T or -5312C/T
This variant is located in a distal enhancer of the REN gene, and several publications link it to variation in the renin response to antihypertensive drugs such as valsartan.[PMID 19509012
]
In general, rs12750834(G;G) homozygotes being treated for high blood pressure are reported to respond better (i.e. either at all or with a greater drop in blood pressure) to angiotensin receptor blockers (ARBs).
