|(A;A)||adult waist 1.8cm larger on average|
|(A;G)||adult waist 0.9cm larger on average|
A study of 14,000 Indian Asian or Caucasian adults indicates that rs12970134(A) alleles are associated with obesity. The average increase in waist circumference is 0.9cm BMI units per risk allele. [PMID 18454146] see also 
|Condition||Waist circumference and related phenotypes|
|95% CI||0.59-1.17) cm increas|
|Trait||Body mass index|
|Title||Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity|
|Odds Ratio||4.38 [3.16-5.60] % SD|
[PMID 19680233] Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs
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[PMID 19073769] Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.
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[PMID 20092643] Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
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[PMID 20694148] A genome-wide association study of the metabolic syndrome in Indian Asian men.
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[PMID 23151679] Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
[PMID 23408508] Obesity-susceptibility loci and the tails of the pediatric BMI distribution
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[PMID 25093408] Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population
|Trait||Type 2 diabetes|
|Title||Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.|
|Odds Ratio||1.08 [1.03-1.12]|
[PMID 25951451] Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes
[PMID 25948074] Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort
[PMID 25966591] [Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population]
[PMID 27186233] The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome.