|(A;A)||adult waist 1.8cm larger on average|
|(A;G)||adult waist 0.9cm larger on average|
A study of 14,000 Indian Asian or Caucasian adults indicates that rs12970134(A) alleles are associated with obesity. The average increase in waist circumference is 0.9cm BMI units per risk allele. [PMID 18454146] see also 
|Condition||Waist circumference and related phenotypes|
|95% CI||0.59-1.17) cm increas|
|Trait||Body mass index|
|Title||Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity|
|Odds Ratio||4.38 [3.16-5.60] % SD|
[PMID 19680233] Replication of Association Between a Common Variant Near Melanocortin-4 Receptor Gene and Obesity-related Traits in Asian Sikhs
[PMID 20181787] A Variant in the Fat Mass and Obesity-Associated Gene (FTO) and Variants near the Melanocortin-4 Receptor Gene (MC4R) Do Not Influence Dietary Intake
[PMID 24670271] Association study of common polymorphisms in MSRA, TFAP2B, MC4R, NRXN3, PPARGC1A, TMEM18, SEC16B, HOXB5 and OLFM4 genes with obesity-related traits among Portuguese children
[PMID 21085626] Investigation of a Genome Wide Association Signal for Obesity: Synthetic Association and Haplotype Analyses at the Melanocortin 4 Receptor Gene Locus
[PMID 21625854] Implication of genetic variants near TMEM18, BCDIN3D/FAIM2, and MC4R with coronary artery disease and obesity in Chinese: a angiography-based study
[PMID 18697794] The common obesity variant near MC4R gene is associated with higher intakes of total energy and dietary fat, weight change and diabetes risk in women.
[PMID 19073769] Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes.
[PMID 19265794] Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry.
[PMID 19478790] The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI.
[PMID 20092643] Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).
[PMID 20127379] From monogenic to polygenic obesity: recent advances.
[PMID 20694148] A genome-wide association study of the metabolic syndrome in Indian Asian men.
[PMID 20712903] Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
[PMID 21283731] FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.
[PMID 21372613] Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention.
[PMID 21736789] A variant near the melanocortin-4 receptor gene regulates postprandial lipid metabolism in a healthy Caucasian population.
[PMID 23049848] Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis
[PMID 23512951] Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program
[PMID 23151679] Strong influence of variants near MC4R on adiposity in children and adults: a cross-sectional study in Indian population
[PMID 23408508] Obesity-susceptibility loci and the tails of the pediatric BMI distribution
[PMID 22869321] Common polymorphism near the MC4R gene is associated with type 2 diabetes: data from a meta-analysis of 123,373 individuals.
[PMID 25093408] Obesity-Related Genomic Loci Are Associated with Type 2 Diabetes in a Han Chinese Population
|Trait||Type 2 diabetes|
|Title||Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.|
|Odds Ratio||1.08 [1.03-1.12]|
[PMID 25951451] Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes
[PMID 25948074] Associations between a common variant near the MC4R gene and serum triglyceride levels in an obese pediatric cohort
[PMID 25966591] [Association of polymorphic variants of FTO and MC4R genes with obesity in a Tatar population]
[PMID 27186233] The effect of interaction between Melanocortin-4 receptor polymorphism and dietary factors on the risk of metabolic syndrome.
[PMID 31429705] MC4R variants rs12970134 and rs17782313 are associated with obese polycystic ovary syndrome patients in the Western region of Saudi Arabia.
[PMID 32228543] Obesity-related loci in TMEM18, CDKAL1 and FAIM2 are associated with obesity and type 2 diabetes in Chinese Han patients.
[PMID 32740722] Role of FTO and MC4R Polymorphisms in Escalating Obesity and Their Indirect Association With Risk of T2D in Indian Population.
[PMID 32770936] The MC4R SNPs, their haplotypes and gene-environment interactions on the risk of obesity.
[PMID 32899047] Association between polymorphism near the MC4R gene and cancer risk: A meta-analysis.