rs1343151
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(C;C) | 0 | normal risk |
(C;T) | 0.8x lower risk for spondylitis | |
(T;T) | 0.8x lower risk for spondylitis |
Reference | GRCh38 38.1/141 |
Chromosome | 1 |
Position | 67253446 |
Gene | IL23R |
is a | snp |
is | mentioned by |
dbSNP | rs1343151 |
dbSNP (classic) | rs1343151 |
ClinGen | rs1343151 |
ebi | rs1343151 |
HLI | rs1343151 |
Exac | rs1343151 |
Gnomad | rs1343151 |
Varsome | rs1343151 |
LitVar | rs1343151 |
Map | rs1343151 |
PheGenI | rs1343151 |
Biobank | rs1343151 |
1000 genomes | rs1343151 |
hgdp | rs1343151 |
ensembl | rs1343151 |
geneview | rs1343151 |
scholar | rs1343151 |
rs1343151 | |
pharmgkb | rs1343151 |
gwascentral | rs1343151 |
openSNP | rs1343151 |
23andMe | rs1343151 |
SNPshot | rs1343151 |
SNPdbe | rs1343151 |
MSV3d | rs1343151 |
GWAS Ctlg | rs1343151 |
GMAF | 0.3237 |
Max Magnitude | 0 |
? | (C;C) (C;T) (T;T) | 28 |
---|---|---|
|
rs1343151 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.8 (p=1.0x10e-5).[PMID 17952073, PMID 18037607]
[PMID 18647855] rs1343151 with rheumatoid arthritis (OR=1.14 [1.06-1.22], P=4x10-4)
rs1343151 was not associated with rheumatoid arthritis in a study of 1,200+ Korean patients. [PMID 19034457]
[PMID 21253534] A;A homozygous individuals showed a strongly reduced risk of Crohn's Disease compared those who were G;G homozygous.
GWAS | |
---|---|
SNP | rs1343151 |
PubMedID | [PMID 17804789] |
Condition | Crohn's disease |
Gene | IL23R |
Risk Allele | |
pValue | 1.00E-008 |
OR | 1.38 |
95% CI | 1.23-1.53 |
[PMID 21285166] Role of rs1343151 IL23R and rs3790567 IL12RB2 Polymorphisms in Biopsy-proven Giant Cell Arteritis
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.
[PMID 17786191] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
[PMID 17901940] Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.
[PMID 18199597] The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis.
[PMID 18470928] IL23R haplotypes provide a large population attributable risk for Crohn's disease.
[PMID 19175939] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.
[PMID 19918037] Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
[PMID 20116410] Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.
[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
[PMID 21253733] Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 21926184] Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets.
[PMID 23054009] Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis
[PMID 23053963] Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
[PMID 23274341] Infliximab-induced psoriasis and psoriasiform skin lesions in pediatric Crohn disease and a potential association with IL-23 receptor polymorphisms.
[PMID 30924147] Are genetic variations in IL-21-IL-23R-IL-17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? Bayesian hierarchical meta-analysis.
- Is a snp
- In dbSNP
- SNPs on chromosome 1
- Has genotype
- Has population
- GWAS
- On chip 23andMe v1
- On chip 23andMe v2
- On chip 23andMe v3
- On chip 23andMe v4
- On chip 23andMe v5
- On chip Ancestry v2c
- On chip Ancestry v2
- On chip FTDNA2
- On chip FTDNA
- On chip HumanOmni1Quad
- On chip Illumina Human 1M
- On chip Ancestry v2d
- Pages using PMID magic links