rs139709573
From SNPedia
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;G) | 5 | Possible link to late-onset Alzheimer's, at least in Icelanders |
| (G;G) | 0 | common/normal |
| Make rs139709573(A;A) |
| Reference | GRCh38.p2 38.2/147 |
| Chromosome | 15 |
| Position | 101646763 |
| Gene | TM2D3 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs139709573 |
| dbSNP (classic) | rs139709573 |
| ClinGen | rs139709573 |
| ebi | rs139709573 |
| HLI | rs139709573 |
| Exac | rs139709573 |
| Gnomad | rs139709573 |
| Varsome | rs139709573 |
| LitVar | rs139709573 |
| Map | rs139709573 |
| PheGenI | rs139709573 |
| Biobank | rs139709573 |
| 1000 genomes | rs139709573 |
| hgdp | rs139709573 |
| ensembl | rs139709573 |
| geneview | rs139709573 |
| scholar | rs139709573 |
| rs139709573 | |
| pharmgkb | rs139709573 |
| gwascentral | rs139709573 |
| openSNP | rs139709573 |
| 23andMe | rs139709573 |
| SNPshot | rs139709573 |
| SNPdbe | rs139709573 |
| MSV3d | rs139709573 |
| GWAS Ctlg | rs139709573 |
| Max Magnitude | 5 |
rs139709573, also known as Pro155Leu or P155L, is a rare variant in the TM2D3 gene on chromosome 15.
At least in Icelanders, although not proven statistically for other Europeans (where it's ten-fold rarer), the rare rs139709573(A) allele was associated with increased risk and earlier onset of late-onset Alzheimer's disease, with an odds ratio of 7.5 (CI:3.5–15.9), p = 6.6x10e-9.[1]
