rs1434536

minus

Geno	Mag	Summary
(A;A)	2	1.94x increased breast cancer risk
(A;G)	1.3	1.29x increased breast cancer risk
(G;G)	0	normal

Reference

GRCh38 38.1/141

Chromosome

4

Position

95154814

Gene

BMPR1B

is a	snp
is	mentioned by
dbSNP	rs1434536
dbSNP (classic)	rs1434536
ClinGen	rs1434536
ebi	rs1434536
HLI	rs1434536
Exac	rs1434536
Gnomad	rs1434536
Varsome	rs1434536
LitVar	rs1434536
Map	rs1434536
PheGenI	rs1434536
Biobank	rs1434536
1000 genomes	rs1434536
hgdp	rs1434536
ensembl	rs1434536
geneview	rs1434536
scholar	rs1434536
google	rs1434536
pharmgkb	rs1434536
gwascentral	rs1434536
openSNP	rs1434536
23andMe	rs1434536
SNPshot	rs1434536
SNPdbe	rs1434536
MSV3d	rs1434536
GWAS Ctlg	rs1434536

GMAF

0.4307

Max Magnitude

2

?

(A;A) (A;G) (G;G)

28

rs1434536 is a SNP reported to potentially represent a miR-125b binding site.

A study of 459 probands from a breast cancer affected sibling pair cohort were recruited from the ECOG study, and in conjunction with 1,145 patient samples from the CGEMS study, led to the conclusion that rs1434536 was associated with increased risk for breast cancer. The odds ratios for rs1434536(A;G) and (A;A) individuals were 1.29 (CI: 0.95-1.74) and 1.94 (CI: 1.40-2.71), respectively (p=1.6x10e-4).[PMID 19738052 ]

[PMID 21556765] A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.

ClinVar
Risk	Rs1434536(A;A)
Alt	Rs1434536(A;A)
Reference	Rs1434536(G;G)
Significance	Non-pathogenic
Disease	Brachydactyly
Variation	info
Gene	BMPR1B
CLNDBN	Brachydactyly
Reversed	1
HGVS	NC_000004.11:g.96075965C>T
CLNSRC
CLNACC	RCV000273899.1,