|(A;A)||0||1.2x higher risk for spondylitis|
|(A;G)||1.2x higher risk for spondylitis|
rs1495965 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 1.2 (p=6.6x10e-6).[PMID 17952073, PMID 18037607]
[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
[PMID 19334001] Contribution of IL23R but not ATG16L1 to Crohn's disease susceptibility in Koreans
|Title||Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behcet's disease susceptibility loci|
|Odds Ratio||1.35 [1.24-1.47]|
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.
[PMID 17786191] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
[PMID 18200510] CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population.
[PMID 18470928] IL23R haplotypes provide a large population attributable risk for Crohn's disease.
[PMID 19175939] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.
[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
[PMID 21304977] An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
[PMID 22378604] Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease.
[PMID 24998354] Determination of IL-23 receptor gene polymorphism in Iranian patients with ankylosing spondylitis
[PMID 29017598] Behçet's disease risk association fine-mapped on the IL23R-IL12RB2 intergenic region in Koreans.
[PMID 29792538] Single-Nucleotide Polymorphisms in IL23R-IL12RB2 (rs1495965) Are Highly Prevalent in Patients with Behcet's Uveitis, and Vary between Populations.