||lowest risk of Podoconiosis
||higher risk (~2x) for podoconiosis
||highest risk (~5x higher) for podoconiosis
rs17612858 represents a variant near the HLA-DQA1 gene, located on chromosome 6.
A relatively small genomewide association study (~200 patients followed by validation) of southern Ethiopians concluded that the rs17612858(T) allele significantly increases risk for podoconiosis, a tropical lymphedema resulting from long-term barefoot exposure to red-clay volcanic soil. Compared to the major (A;A) homozygote, the odds ratio was 1.7 (CI: 1 - 2.7) for (A;T) heterozygotes and 4.6 (CI: 2.6 - 8) for (T;T) minor allele homozygotes.[PMID 22455414]