|(-;-)||2||less favorable clinical outcome when on antipsychotics|
|(-;C)||2||1.3x increased adenoma recurrence risk|
rs1799732 is a SNP in the D2 dopamine receptor gene DRD2 gene. Although dbSNP indicates the alleles as (C) or (-) (i.e. a deletion), investigators report the alleles as (C) or (T).
In a study of individuals in the Polyp Prevention Trial with any, multiple (>/=2) or advanced colorectal adenoma recurrence after 4 years, compared to those without adenoma recurrence, rs1799732(C;T) individuals were significantly associated with all adenoma recurrence (odds ratio 1.30, CI: 1.01-1.69). The authors speculate this increased risk of adenoma recurrence (and an association with colorectal cancer) may be related to SNP-associated differences in alcohol and fat intake.[19065655?dopt=Abstract PMID 19065655]
23andMe blog Alcoholism related
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[PMID 19547807] Association between the DRD2-141C Insertion/Deletion polymorphism and schizophrenia
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[PMID 18563706] The impact of genetic variation in DRD2 and SLC6A3 on smoking cessation in a cohort of participants 1 year after enrollment in a lung cancer screening study.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
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[PMID 19390575] Lung cancer susceptibility model based on age, family history and genetic variants.
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[PMID 20191112] The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives.
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[PMID 22382052] A DRD2 and ANKK1 haplotype is associated with nicotine dependence.
[PMID 22574669] Dopamine receptors D1 and D2 are related to observed maternal behavior.
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[PMID 27121382] Incorporating epistasis interaction of genetic susceptibility single nucleotide polymorphisms in a lung cancer risk prediction model.