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From SNPedia

Geno Mag Summary
(C;C) 0 normal
(C;T) 1.8 Slightly higher risk for lumbar disc disease
(T;T) 2.3 Increased waist circumference and a much greater risk of Intervertebral disc disease
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs1800587
1000 genomesrs1800587
GWAS Ctlgrs1800587
Max Magnitude2.3
? (C;C) (C;T) (T;T) 28

PubMed [PMID 17471097]
Affy Probeset SNP_A-8486970
Affy Orientation same
On GW 5.0 0
Alleles A/B C/T
Ancestral C
Population Caucasian
Allele T
Case Freq.
Control Freq.
Odds Ratio Het 1.31
Odds Ratio Hom 7.87
Odds Ratio All
Disease Intervertebral disc disease (IDD)

rs1800587, also known as C-889T, is a SNP in the IL-1 alpha IL1A gene.

A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1800587(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers. [PMID 18716798]

rs1800587 increases susceptibility to Intervertebral disc disease 1.31 times for (C;T) heterozygotes and 7.87 times for (T;T) homozygotes [PMID 17471097]

This SNP has also been reported to be associated with Alzheimer's disease in a few studies, but probably ruled out in even more studies, such as this one [PMID 19158434].

[PMID 19619703OA-icon.png] Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study

[PMID 20157068] Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study

[PMID 20565898OA-icon.png] Association of IL1A and IL1B loci with primary open angle glaucoma

[PMID 20116409] The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis

[PMID 21070631OA-icon.png] The dopamine beta-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project

[PMID 21637534OA-icon.png] Interleukin-8-251T > A, Interleukin-1?-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease

[PMID 22216303OA-icon.png] Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice

[PMID 21672595] Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis

[PMID 22285486] Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis

[PMID 21509504OA-icon.png] Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study

[PMID 15726497OA-icon.png] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16078996OA-icon.png] Association study of functional genetic variants of innate immunity related genes in celiac disease.

[PMID 16519819OA-icon.png] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16617143OA-icon.png] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.

[PMID 16719905OA-icon.png] Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16916584] Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.

[PMID 17205326] The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures.

[PMID 17327408OA-icon.png] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17459217] [A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis].

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18576312OA-icon.png] A broad analysis of IL1 polymorphism and rheumatoid arthritis.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18633131OA-icon.png] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870OA-icon.png] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 19035492OA-icon.png] Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.

[PMID 19043479OA-icon.png] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

[PMID 19066394OA-icon.png] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19131662OA-icon.png] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19155622] Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.

[PMID 19263529OA-icon.png] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901OA-icon.png] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392OA-icon.png] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19742166OA-icon.png] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 20031567OA-icon.png] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

[PMID 20192980] The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.

[PMID 20196868OA-icon.png] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

[PMID 20347268] Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.

[PMID 20353565OA-icon.png] Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

[PMID 20574532OA-icon.png] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

[PMID 20811626OA-icon.png] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20934174] Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians.

[PMID 21205020] Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.

[PMID 21385326] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.

[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.

[PMID 22341060] Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism.

[PMID 23050050OA-icon.png] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up

[PMID 22723975OA-icon.png] Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study

[PMID 23216199] Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: gender and subpopulation differences

[PMID 24103372] Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia

[PMID 24357513] The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population

[PMID 24460370OA-icon.png] Relationship Between IL1 Gene Polymorphisms and Periodontal Disease in Japanese Women

[PMID 24477584] Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population

[PMID 21962386] The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.

[PMID 22623017] Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.

[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.

[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 23594042] Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.

[PMID 23722873] Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.

[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population

[PMID 25758360OA-icon.png] Saving more teeth-a case for personalized care

[PMID 25865535OA-icon.png] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia

[PMID 25902400] Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women

[PMID 26578206OA-icon.png] Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis

[PMID 29023524OA-icon.png] Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.

[PMID 29666343] Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis.

[PMID 30130760] Genes Regulating Immune Response and Amelogenesis Interact in Increasing the Susceptibility to Molar-Incisor Hypomineralization.

[PMID 30142580] Antagonistic effect of IL1 variants in periodontitis and external apical root resorption: Evidence from a literature review.

[PMID 31324923OA-icon.png] Interleukin-1 Genotype in Periodontitis.

[PMID 31618972OA-icon.png] Polymorphisms of Proinflammatory Cytokines in Relation to APOE Epsilon 4 and Risk of Alzheimer's Disease in the Lithuanian Population.

[PMID 32391092OA-icon.png] Association of angiogenesis and inflammation-related gene functional polymorphisms with early-stage breast cancer prognosis.

[PMID 32904982OA-icon.png] Interleukin-1A and interleukin-1B gene polymorphisms in gastroesophageal reflux disease.