|(C;T)||2||increased risk of coronary artery disease|
|(T;T)||2.5||increased risk of coronary artery disease|
|?||(C;C) (C;T) (T;T)||28|
rs1800888, also known as Ile164, is a SNP in the beta 2 adrenergic receptor ADRB2 gene. The rs1800888(T) encodes the much rarer Ile allele.
In a study of 330 patients undergoing percutaneous coronary intervention (PCI), patients carrying a rs1800888(T) allele showed a higher incidence of new acute myocardial infarction (17.5% vs. 4.5%, p = 0.001), new PCI (37.5% vs. 13.1%, p < 0.0001), and cardiac death (10% vs. 3.1%, p = 0.036). Regression analysis identified rs1800888(T) as an independent predictor of cardiac death (odds ratio 3.731, CI: 1.004 - 13.867, p = 0.049) and an overall major adverse cardiac event (odds ratio 4.1, CI: 1.945 - 8.640, p = 0.0001).
A replication study was done on a population of 150 patients with peripheral artery disease. The presence of the rs1800888(T) allele was associated with a higher incidence of acute myocardial infarction (54.5% vs. 25.2%, p = 0.035) or combined events (acute myocardial infarction, PCI, or coronary artery bypass graft) (63.6% vs. 30.9%, p = 0.027).[PMID 18940527]
[PMID 18647184] Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women
[PMID 21883537] ?(2) -Adrenergic Receptor Thr164Ile Polymorphism, Blood Pressure and Ischaemic Heart Disease in 66,750 Individuals
|CLNDBN||Beta-2-adrenoreceptor agonist, reduced response to|
|CLNSRC||OMIM Allelic Variant UniProtKB (protein)|
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