rs1937506 has been reported in a large study to be associated with high blood pressure.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.33 (CI 1.04-1.69), and for homozygotes, 1.60 (CI 1.26-2.02). [PMID 17554300
]
As follows from results of Replication of the Wellcome Trust genome-wide association study
of essential hypertension this SNP (rs1937506) only one of the top 6 SNPs which might be associated with essential hypertension in
Americans of European origin. This SNP shows a significant but opposite effect in Americans of
Hispanic origin. Each additional G allele of rs1937506 is associated with a 24.9 mmHg
decrease of systolic blood pressure (SBP) in European Americans and with a 27.7 mmHg increase in Hispanic Americans.
Considering diastolic blood pressure (DBP) each additional G allele is associated with a 8.7 mmHg decrease of DBP in European Americans, whereas the results are non-significant for Hispanic Americans. [PMID: 18523456]
[PMID 19439027] Dissecting complex traits: recent advances in hypertension genomics.
[PMID 21228780] Novel genetic variations associated with salt sensitivity in the Korean population.
]
