| Geno
|
Mag
|
Summary
|
| (A;A)
|
1.2
|
slight association with longer life (longevity)
|
| (A;G)
|
1.1
|
slight association with longer life (longevity)
|
| (G;G)
|
0
|
common/normal
|
A genome-wide association meta-analysis of 7,729 long-lived individuals of European descent (≥ 85 years) and 16,121 younger controls (<65 years), followed by replication in an additional set of 13,060 long-lived individuals and 61,156 controls, found a (slight) association with longevity, as reflected by survival to ages beyond 90 years, for rs2149954, (OR 1.10, p = 1.74 × 10e-8). The less common rs2149954(A) allele (as represented in dbSNP orientation) is associated with low blood pressure in middle age and decreased cardiovascular mortality risk (independent of blood pressure).[PMID 24688116
]
[PMID 27707806] Replication of Genome-Wide Association Study Findings of Longevity in White, African American, and Hispanic Women: The Women's Health Initiative.
]
