| Geno
|
Mag
|
Summary
|
| (C;C)
|
2
|
0.45x reduced risk for breast cancer
|
| (C;G)
|
0
|
|
| (G;G)
|
0
|
common on affy axiom data
|
rs2230782, also known as Q586H, is a SNP in the nuclear receptor coactivator 3 NCOA3 gene; this gene is also known as SRC-3 or AIB1.
A study of 1,218 familial BRCA1/2-mutation negative breast cancer cases and 1,509 matched controls strengthened a (previously reported) protective effect of rs2230782. The reported odds ratio for rs2230782(C;C) homozygotes is 0.45 (CI: 0.21-0.98).[PMID 20003447
]
[PMID 19470168] NPAS2 and PER2 are linked to risk factors of the metabolic syndrome.
[PMID 20180986] CLOCK is suggested to associate with comorbid alcohol use and depressive disorders.
]
