rs2237897
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common |
| (C;T) | 1.2 | 1.2x increased risk for diabetic nephropathy in some populations |
| (T;T) | 1.4 | 1.4x increased risk for diabetic nephropathy in some populations |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 2837316 |
| Gene | KCNQ1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs2237897 |
| dbSNP (classic) | rs2237897 |
| ClinGen | rs2237897 |
| ebi | rs2237897 |
| HLI | rs2237897 |
| Exac | rs2237897 |
| Gnomad | rs2237897 |
| Varsome | rs2237897 |
| LitVar | rs2237897 |
| Map | rs2237897 |
| PheGenI | rs2237897 |
| Biobank | rs2237897 |
| 1000 genomes | rs2237897 |
| hgdp | rs2237897 |
| ensembl | rs2237897 |
| geneview | rs2237897 |
| scholar | rs2237897 |
| rs2237897 | |
| pharmgkb | rs2237897 |
| gwascentral | rs2237897 |
| openSNP | rs2237897 |
| 23andMe | rs2237897 |
| SNPshot | rs2237897 |
| SNPdbe | rs2237897 |
| MSV3d | rs2237897 |
| GWAS Ctlg | rs2237897 |
| GMAF | 0.1589 |
| Max Magnitude | 1.4 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
- rs2237897, P = 6.8 times 10-13; OR = 1.41, 95% CI = 1.29–1.55)
A study of 754 type-2 diabetes patients plus a meta-analysis concluded that rs2237897(T) was significantly associated with susceptibility to diabetic nephropathy in T2D Japanese subjects (odds ratio = 1.22, CI: 1.10-1.34, corrected p = 0.01).[PMID 20056949
]
[PMID 19366866] Association of type 2 diabetes candidate polymorphisms in KCNQ1 with incretin and insulin secretion
| GWAS snp | |
|---|---|
| PMID | [PMID 18711366] |
| Trait | Type 2 diabetes |
| Title | SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations |
| Risk Allele | C |
| P-val | 1E-16 |
| Odds Ratio | 1.33 [1.24-1.41] |
[PMID 19448982] Variants in KCNQ1 are associated with susceptibility to type 2 diabetes in the population of mainland China
[PMID 19516902] The type 2 diabetes associated minor allele of rs2237895 KCNQ1 associates with reduced insulin release following an oral glucose load
[PMID 19575309] Association study of four variants in KCNQ1 with type 2 diabetes mellitus and premature coronary artery disease in a Chinese population
[PMID 19308350] Variations in KCNQ1 are associated with type 2 diabetes and beta cell function in a Chinese population
[PMID 19252135] Genetic variation in KCNQ1 associates with fasting glucose and beta-cell function: a study of 3,734 subjects comprising three ethnicities living in Singapore.
[PMID 19556355] Common variants in KCNQ1 are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
[PMID 20174558] A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.
[PMID 20701788] KCNQ1 gene polymorphisms are associated with lipid parameters in a Chinese Han population.
[PMID 21261977] Variants in KCNQ1 increase type II diabetes susceptibility in South Asians: a study of 3,310 subjects from India and the US.
[PMID 21289621] Effects of KCNQ1 polymorphisms on the therapeutic efficacy of oral antidiabetic drugs in Chinese patients with type 2 diabetes.
[PMID 21767287] Replication of genome-wide association signals of type 2 diabetes in Han Chinese in a prospective cohort.
[PMID 22696034] KCNQ1 SNPS and susceptibility to diabetic nephropathy in East Asians with type 2 diabetes.
[PMID 23271129] Meta-analysis of the effect of KCNQ1 gene polymorphism on the risk of type 2 diabetes
[PMID 23786590] Common Variants in KCNQ1 Confer Increased Risk of Type 2 Diabetes and Contribute to the Diabetic Epidemic in East Asians: A Replication and Meta-Analysis
[PMID 23298195] Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
[PMID 23544998] Association of TRPC1 gene polymorphisms with type 2 diabetes and diabetic nephropathy in Han Chinese population.
| GWAS snp | |
|---|---|
| PMID | [PMID 24390345]
|
| Trait | Type 2 diabetes |
| Title | Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. |
| Risk Allele | C |
| P-val | 9E-15 |
| Odds Ratio | 1.31 [1.22-1.41] |
[PMID 25749274] Joint effect of CENTD2 and KCNQ1 polymorphisms on the risk of type 2 diabetes mellitus among chinese han population
[PMID 31324086] SNP in KCNQ1 Gene is Associated with Susceptibility to Diabetic Nephropathy in Subjects with Type 2 Diabetes in India.
