||Associated with PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not males
||One copy of risk allele = associated with mildly increased chance of PTSD, hyperarousal, impaired fear discrimination in traumatized females, but not males
||Normal variant of snp associated with PTSD, hyperarousal in females.
An SNP in a putative estrogen response element within the ADCYAP1R1 gene. C is the risk allele - associated with PTSD, hyperarousal in females.
[PMID 21350482] Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). Predicts Post-traumatic stress disorder diagnoses and symptoms in females only. This may occur due to oestrogen regulation of ADCYAP1R1. Total PTSD symptoms are differentially associated with rs2267735 genotype (CC is high-risk variant) in females (p ≤ 0.001). Hyperarousal is the most robustly associated symptom with rs2267735 genotype (p = 0.0009). In a dominant/recessive model, even after controlling for childhood trauma, adult trauma, and age, genotype predicts total PTSD symptoms (p ≤ 0.001) and hyperarousal symptoms (p ≤ 0.0001). Fear discrimination (CS+ Startle minus CS− Startle) is impaired in females with rs2267735 ‘CC’ genotype. Dark enhanced startle (StartleDark – StartleLight) is significantly increased in females with rs2267735 ‘CC’ genotype.
[PMID 23280952] ADCYAP1R1 GENOTYPE, POSTTRAUMATIC STRESS DISORDER, AND DEPRESSION AMONG WOMEN EXPOSED TO CHILDHOOD MALTREATMENT
[PMID 23394710] PAC1 receptor (ADCYAP1R1) genotype is associated with PTSD's emotional numbing symptoms in Chinese earthquake survivors
[PMID 23328528] ADCYAP1R1 and asthma in Puerto Rican children.
[PMID 23505260] ADCYAP1R1 genotype associates with post-traumatic stress symptoms in highly traumatized African-American females.
[PMID 25680674] Neural Mechanism of a Sex-Specific Risk Variant for Posttraumatic Stress Disorder in the Type I Receptor of the Pituitary Adenylate Cyclase Activating Polypeptide
[PMID 32590837] Impact of ADCYAP1R1 genotype on longitudinal fear conditioning in children: interaction with trauma and sex.