||1.1x increased breast cancer risk
||1.9x increased breast cancer risk
rs2268578 is a SNP in the lumican LUM gene.
Two populations of patients with breast cancer, comprising ~800 cases from the Mayo Clinic and ~4,500 cases from East Anglia, England, were analyzed for SNP associations in the decorin and lumican genes. rs2268578 was associated with breast cancer in both populations; in combined analyses, the odds ratio for rs2268578(C;T) was 1.1 (CI: 0.9-1.2) and 1.9 (CI: 1.3-2.8, p 2 df = 0.001) for homozygotes. [PMID 19036156]
[PMID 19843670] Association of Breast Cancer Susceptibility Variants with Risk of Pancreatic Cancer
[PMID 20360993] Candidate gene study to investigate the genetic determinants of normal variation in central corneal thickness.