rs2546890

Associated with multiple sclerosis

Orientation

plus

Stabilized

plus

Geno	Mag	Summary
(A;A)	1	Higher risk of multiple sclerosis
(A;G)	1	Higher risk of multiple sclerosis
(G;G)	1	Lower risk of multiple sclerosis

Reference

GRCh38 38.1/141

Chromosome

5

Position

159332892

Gene

LOC285626

is a	snp
is	mentioned by
dbSNP	rs2546890
dbSNP (classic)	rs2546890
ClinGen	rs2546890
ebi	rs2546890
HLI	rs2546890
Exac	rs2546890
Gnomad	rs2546890
Varsome	rs2546890
LitVar	rs2546890
Map	rs2546890
PheGenI	rs2546890
Biobank	rs2546890
1000 genomes	rs2546890
hgdp	rs2546890
ensembl	rs2546890
geneview	rs2546890
scholar	rs2546890
google	rs2546890
pharmgkb	rs2546890
gwascentral	rs2546890
openSNP	rs2546890
23andMe	rs2546890
SNPshot	rs2546890
SNPdbe	rs2546890
MSV3d	rs2546890
GWAS Ctlg	rs2546890

GMAF

0.4334

Max Magnitude

1

?	(A;A) (A;G) (G;G)	28

23andMe blog multiple sclerosis rs2546890 IL12B G 0.87

GWAS snp
PMID	[PMID 20953188]
Trait
Title	Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2
Risk Allele	A
P-val	1E-20
Odds Ratio	1.5400 [1.32-1.79] (Panel A)

GWAS snp
PMID	[PMID 22190364]
Trait
Title	Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
Risk Allele	A
P-val	8E-8
Odds Ratio	1.1600 None

GWAS snp
PMID	[PMID 21833088]
Trait
Title	Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
Risk Allele	A
P-val	1E-11
Odds Ratio	1.1100 [1.10-1.13]

[PMID 16600026] Asthma families show transmission disequilibrium of gene variants in the vitamin D metabolism and signalling pathway.

[PMID 19956101] Overview of the Rapid Response data.

[PMID 19956104] Evaluation of IL12B as a candidate type I diabetes susceptibility gene using data from the Type I Diabetes Genetics Consortium.

[PMID 23785401] Association of Genetic Markers with CSF Oligoclonal Bands in Multiple Sclerosis Patients