rs267606617

plus

Geno	Mag	Summary
(A;A)	0	common in clinvar
(G;G)	5	High risk of developing hearing loss after taking aminoglycoside antibiotics

Make rs267606617(A;G)

Reference

GRCh38.p7 38.3/150

Chromosome

MT

Position

1555

is a	snp
is	mentioned by
dbSNP	rs267606617
dbSNP (classic)	rs267606617
ClinGen	rs267606617
ebi	rs267606617
HLI	rs267606617
Exac	rs267606617
Gnomad	rs267606617
Varsome	rs267606617
LitVar	rs267606617
Map	rs267606617
PheGenI	rs267606617
Biobank	rs267606617
1000 genomes	rs267606617
hgdp	rs267606617
ensembl	rs267606617
geneview	rs267606617
scholar	rs267606617
google	rs267606617
pharmgkb	rs267606617
gwascentral	rs267606617
openSNP	rs267606617
23andMe	rs267606617
SNPshot	rs267606617
SNPdbe	rs267606617
MSV3d	rs267606617
GWAS Ctlg	rs267606617

Max Magnitude

5

m.1555A>G; also commonly known as A1555G

First reported in 1993 and subsequently replicated in numerous studies (but not all), individuals who's mitochondria carry a G at position 1555, i.e. rs267606617(G) mitochondria, are at quite high risk of developing permanent hearing loss (deafness) when taking after receiving aminoglycoside antibiotics such as gentamicin, amikacin, tobramycin, neomycin, and streptomycin.

The incidence of inner ear toxicity (ototoxicity) varies from 7 to 90% depending of the types of antibiotics used, susceptibility of the patient to such antibiotics, and the duration of antibiotics administration.Wikipedia

ClinVar
Risk	Rs267606617(G;G)
Alt	Rs267606617(G;G)
Reference	Rs267606617(A;A)
Significance	Drug-response
Disease	Aminoglycoside-induced deafness Deafness Cardiomyopathy aminoglycoside antibacterials response - Toxicity/ADR not provided
Variation	info
Gene
CLNDBN	Aminoglycoside-induced deafness Deafness, nonsyndromic sensorineural, mitochondrial Cardiomyopathy, restrictive aminoglycoside antibacterials response - Toxicity/ADR not provided
Reversed	0
HGVS	NC_012920.1:m.1555A>G
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000010254.5, RCV000010255.6, RCV000010256.5, RCV000211153.1, RCV000224935.1,