rs28399433

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(G;G)	2	Reduced CYP2A6 metabolism; impaired nicotine metabolism?
(G;T)	1	Reduced CYP2A6 metabolism; impaired nicotine metabolism?
(T;T)	0

Reference

GRCh38 38.1/141

Chromosome

19

Position

40850474

Gene

CYP2A6

is a	snp
is	mentioned by
dbSNP	rs28399433
dbSNP (classic)	rs28399433
ClinGen	rs28399433
ebi	rs28399433
HLI	rs28399433
Exac	rs28399433
Gnomad	rs28399433
Varsome	rs28399433
LitVar	rs28399433
Map	rs28399433
PheGenI	rs28399433
Biobank	rs28399433
1000 genomes	rs28399433
hgdp	rs28399433
ensembl	rs28399433
geneview	rs28399433
scholar	rs28399433
google	rs28399433
pharmgkb	rs28399433
gwascentral	rs28399433
openSNP	rs28399433
23andMe	rs28399433
SNPshot	rs28399433
SNPdbe	rs28399433
MSV3d	rs28399433
GWAS Ctlg	rs28399433

GMAF

0.1336

Max Magnitude

2

rs28399433, also known as -47A>C, is a SNP in the CYP2A6 gene.

[PMID 19339270] Genetic Associations of 115 Polymorphisms with Cancers of the Upper Aerodigestive Tract across 10 European Countries: The ARCAGE Project.

[PMID 22046326] 'Smoking Genes': A Genetic Association Study

[PMID 19371316] CYP2B6 (c.516G-->T) and CYP2A6 (*9B and/or *17) polymorphisms are independent predictors of efavirenz plasma concentrations in HIV-infected patients.

[PMID 19659438] CYP2B6 variants and plasma efavirenz concentrations during antiretroviral therapy in Port-au-Prince, Haiti.

[PMID 24080498] Pharmacogenetic associations with plasma efavirenz concentrations and clinical correlates in a retrospective cohort of Ghanaian HIV-infected patients